Comparison of two treatment approaches for prostate cancer: intensity‐modulated radiation therapy combined with I125 seed‐implant brachytherapy or I125 seed‐implant brachytherapy alone
نویسندگان
چکیده
The purpose of the present study was to assess the results of two different treatment approaches for clinically localized prostate cancer: intensity-modulated radiation therapy (IMRT) followed by 125I seed-implant brachytherapy and 125I seed-implant brachytherapy alone. We studied our 30 most recent consecutive patients. The sample population consisted of 15 cases treated with IMRT (50.4 Gy) followed by 125I seed-implant boost (95 Gy), and 15 cases treated with 125I seed implant only (144 Gy). We analyzed established dosimetric indices and various clinical parameters. In addition, we also evaluated and compared the acute urinary morbidities of the two treatment approaches, as assessed by the international prostate symptom score (IPSS). In our series, acute urinary morbidity was slightly increased with IMRT followed by 125I seed-implant brachytherapy as compared with 125I seed-implant brachytherapy alone. In addition, we observed no statistically significant correlation between the IPSS and the maximum or mean urethral dose. The combination of IMRT and seed-implant brachytherapy presents an alternative opportunity to treat clinically localized prostate cancer. The full potential of the procedure needs to be further investigated.
منابع مشابه
Comparison of implant quality between intraoperatively built custom-linked seeds and loose seeds in permanent prostate brachytherapy using sector analysis
We compared the implant quality of intraoperatively built custom-linked (IBCL) seeds with loose seeds in permanent prostate brachytherapy. Between June 2012 and January 2015, 64 consecutive prostate cancer patients underwent brachytherapy with IBCL seeds (n = 32) or loose seeds (n = 32). All the patients were treated with 144 Gy of brachytherapy alone. Brachytherapy was performed using a dynami...
متن کاملIntensity Modulated Proton Therapy as a Boost Treatment after Prostate Seed Implant: A Treatment Planning Study
Purpose: Combination of Prostate Seed Implant (PSI) with External Beam Radiation Therapy (EBRT) remains as an attractive option for patients with intermediate or high-risk prostate cancer. One of the most widely used approaches is to use external beam radiation therapy (EBRT) to deliver boost doses after permanent prostate seed implant (PSI). In this study, the feasibility of using Intensity Mo...
متن کاملIntensity-Modulated vs. Conformal Radiotherapy after Prostate Seed Implant Brachytherapy Regarding Summed Rectal Dose
Purpose: To disclose effectiveness of substitution of conformal radiotherapy (CRT) with intensity-modulated radiotherapy (IMRT) in combined with 125I permanent seed brachytherapy(BT) in reducing a rectal dose-volume parameter recently proven to be correlated with late rectal bleeding after the combined radiotherapy. Materials/Methods: A CT image set obtained a month after BT was used for CRT an...
متن کاملHypofractionated image guided radiation therapy followed by prostate seed implant boost for men with newly diagnosed intermediate and high risk adenocarcinoma of the prostate: Preliminary results of a phase 2 prospective study
PURPOSE A phase 2 protocol was designed and implemented to assess the toxicity and efficacy of hypofractionated image guided intensity modulated radiation therapy (IG-IMRT) combined with low-dose rate 103Pd prostate seed implant for treatment of localized intermediate- and high-risk adenocarcinoma of the prostate. METHODS AND MATERIALS This is a report of an interim analysis on 24 patients en...
متن کاملThe effect of tissue composition of the prostate on the dose calculation for 125 I brachytherapy
P Introduction ermanent seed-implant treatment using I radionuclide is currently a standard procedure for early-stage prostate carcinoma, and the method is now considered comparable to external-beam radiation therapy and prostatectomy. As with external beam radiation therapy, permanent seed implant treatment of the prostate requires a dose-outcome correction, pointing out the importance of the ...
متن کامل